DRUGS CONTRAINDICATED IN PREGNANCY

DRUGS CONTRAINDICATED IN PREGNANCY
This chart represents information on select drugs that are contraindicated (Pregnancy category X) for women who are pregnant. This is not an inclusive list of products that carry that pregnancy category. Those drugs that are contraindicated at a certain phase of the pregnancy are listed next to the product name. For more information on specific drug monographs, see product entries or consult the manufacturer.
ALLERGIC DISORDERS
Vistaril (hydroxyzine) Early pregnancy
CARDIOVASCULAR SYSTEM
Advicor (niacin ext-rel/lovastatin) Aggrenox (dipyridamole/aspirin) 3rd trimester Altoprev (lovastatin) Bayer (aspirin) 3rd trimester Caduet (amlodipine/atorvastatin) Coumadin (warfarin sodium) Crestor (rosuvastatin) Ecotrin (aspirin) 3rd trimester Juvisync (sitagliptin/simvastatin) Lescol (fluvastatin) Lescol XL (fluvastatin)	Letairis (ambrisentan) Lipitor (atorvastatin) Livalo (pitavastatin) Mevacor (lovastatin) Multaq (dronedarone) Pravachol (pravastatin) Simcor (niacin ext-rel/simvastatin) Tracleer (bosentan) Vytorin (ezetimibe/simvastatin) Zocor (simvastatin)
CENTRAL NERVOUS SYSTEM
Beyaz (drospirenone/ethinyl estradiol) Dalmane (flurazepam HCl) Doral (quazepam) Estazolam	Halcion (triazolam) Restoril (temazepam) Vistaril (hydroxyzine) Early pregnancy Yaz (drospirenone/ethinyl estradiol)
DERMATOLOGICAL DISORDERS
Amnesteem (isotretinoin) Avage (tazarotene) Beyaz (drospirenone/ethinyl estradiol) Carac (fluorouracil) Claravis (isotretinoin) Efudex (fluorouracil) Estrostep Fe (norethindrone acetate/ethinyl estradiol) Fluoroplex (fluorouracil) Loryna (drospirenone/ethinyl estradiol) Ortho Tri-Cyclen 28 (norgestimate/ethinyl estradiol) Propecia (finasteride) Silvadene (silver sulfadiazine) Late pregnancy Solage (mequinol/tretinoin)	Solaraze (diclofenac sodium) 3rd trimester Soriatane (acitretin) Sotret (isotretinoin) SSD (silver sulfadiazine) Late pregnancy SSD AF (silver sulfadiazine) Late pregnancy Tazorac (tazarotene) Tilia Fe (norethindrone acetate/ethinyl estradiol) Tri-Legest 21 (norethindrone acetate/ethinyl estradiol) Tri-Legest Fe (norethindrone acetate/ethinyl estradiol) Tri-previfem (norgestimate/ethinyl estradiol) Tri-sprintec (norgestimate/ethinyl estradiol) Yaz (drospirenone/ethinyl estradiol)
ENDOCRINE DISORDERS
Androderm (testosterone) Androgel (testosterone) Android (methyltestosterone) Axiron (testosterone) Delatestryl (testosterone enanthate) Depo-testosterone (testosterone cypionate) Egrifta (tesamorelin) Fluoxymesterone Fortesta (testosterone) Juvisync (sitagliptin/simvastatin)	Lupron (leuprolide acetate) Methitest (methyltestosterone) Oxandrin (oxandrolone) Striant (testosterone) Supprelin LA (histrelin acetate) Synarel (nafarelin) Testim (testosterone) Testred (methyltestosterone) Virilon (methyltestosterone)
GASTROINTESTINAL TRACT
Bellergal-S (phenobarbital/ergotamine tartrate)	Cytotec (misoprostol)
INFECTIONS & INFESTATIONS
Bactrim (sulfamethoxazole/trimethoprim) 3rd trimester Copegus (ribavirin) Flagyl (metronidazole) 1st trimester for trichomoniasis Furadantin (nitrofurantoin) Pregnancy at term Gantrisin (sulfisoxazole) 3rd trimester Grifulvin V (griseofulvin) Gris-Peg (griseofulvin) Macrobid (nitrofurantoin as macrocrystals and monohydrate) Pregnancy at term	Macrodantin (nitrofurantoin macrocrystals) Pregnancy at term Rebetol (ribavirin) Rebetron (ribavirin/interferon alfa -2b) Septra (sulfamethoxazole/trimethoprim) 3rd trimester Sulfadiazine Pregnancy at term Tindamax (tinidazole) 1st trimester Urobiotic-250 (oxytetracycline HCl/sulfamethizole/phenazopyridine) Late pregnancy Virazole (ribavirin)
METABOLIC DISORDERS
Zavesca (miglustat)
MUSCULOSKELETAL DISORDERS
Advil (ibuprofen) 3rd trimester Aleve (naproxen sodium) 3rd trimester Ansaid (flurbiprofen) Late pregnancy Arava (leflunomide) Arthrotec (diclofenac sodium/ misoprostol) Bayer (aspirin) 3rd trimester BC Arthritis Strength (aspirin/caffeine/salicylamide) 3rd trimester Cataflam (diclofenac potassium) Late pregnancy Celebrex (celecoxib) 3rd trimester Choline magnesium trisalicylate Pregnancy at term Dantrium (dantrolene) Daypro (oxaprozin) 3rd trimester Diflunisal 3rd trimester Duexis (ibuprofen/famotidine) Late pregnancy (≥30 wks) Ecotrin (aspirin) 3rd trimester Etodolac Late pregnancy	Evista (raloxifene HCl) Feldene (piroxicam) Late pregnancy Ketoprofen Late pregnancy Mobic (meloxicam) 3rd trimester Motrin (ibuprofen) 3rd trimester Nabumetone 3rd trimester Nalfon (fenoprofen calcium) 3rd trimester Naprelan (naproxen) 3rd trimester Prevacid Naprapac (lansoprazole/naproxen) 3rd trimester Probenecid + Colchicine Rheumatrex (methotrexate sodium) Salsalate 3rd trimester Soma Compound w. Codeine (carisoprodol/aspirin/codeine) 3rd trimester Vimovo (naproxen/esomeprazole) Late pregnancy (≥ 30 wks) Voltaren (diclofenac sodium) Late pregnancy
NEOPLASMS
Bexxar (tositumomab) Casodex (bicalutamide) Delestrogen (estradiol valerate) Efudex (fluorouracil) Eligard (leuprolide acetate) Estrace (estradiol) Evista (raloxifene HCl) Firmagon (degarelix) Fluoxymesterone	Menest (esterified estrogens) Revlimid (lenalidomide) Targretin (bexarotene) Thalomid (thalidomide) Trelstar (triptorelan pamoate) Trexall (methotrexate) Vantas (histrelin acetate) Zytiga (abiraterone acetate)
NUTRITION
Didrex (benzphetamine) Fosteum (genistein/citrated zinc/cholecalciferol) Megace ES (megestrol acetate)	Megace Suspension (megestrol acetate) Xenical (orlistat)
OB/GYN
ALL ORAL CONTRACEPTIVES ALL HORMONE REPLACEMENT THERAPY Advil (ibuprofen) 3rd trimester Aleve (naproxen sodium) 3rd trimester Aygestin (norethindrone acetate) Betadine douche (povidone-iodine) Bravelle (urofollitropin) Cataflam (diclofenac potassium) Late pregnancy Celebrex (celecoxib) 3rd trimester Cetrotide (cetrorelix) Clomid (clomiphene citrate) Depo-subQ provera (medroxyprogesterone acetate) Endometrin (micronized progesterone) Ectopic pregnancy Flagyl (metronidazole) 1st trimester for trichomoniasis Follistim (follitropin beta) Ganirelex acetate Gonal-F (follitropin alfa) Lupron Depot (leuprolide acetate)	Luveris (lutropin alfa) Menopur (menoptropins) Methergine (methylergonovine) Midol cramp (ibuprofen) 3rd trimester Midol menstrual (acetaminophen/caffeine/pyrilamine) 3rd trimester Midol PMS (acetaminophen/ pamabrom/pyrilamine) 3rd trimester Midol teen (acetaminophen/ pamabrom) 3rd trimester Mifeprex (mifepristone) Motrin (ibuprofen) 3rd trimester Naprelan (naproxen) 3rd trimester Ovidrel (choriogonadotropin alfa) Ponstel (mefenamic acid) Late pregnancy Repronex 75 IU (follicle-stimulating hormone/luteinizing hormone) Repronex 150 IU (follicle-stimulating hormone/luteinizing hormone) Serophene (clomiphene citrate) Synarel (nafarelin acetate) Tindamax (tinidazole) 1st trimester Zoladex (goserelin)
PAIN & PYREXIA
Advil (ibuprofen) 3rd trimester Advil Migraine (ibuprofen) 3rd trimester Aleve (naproxen sodium) 3rd trimester Bayer (aspirin) 3rd trimester BC Original Formula (aspirin/caffeine/salicylamide) 3rd trimester Cafergot (ergotamine tartrate/ caffeine) Caldolor (ibuprofen) 3rd trimester Cataflam (diclofenac potassium) Late pregnancy Celebrex (celecoxib) 3rd trimester Choline magnesium trisalicylate Pregnancy at term Combunox (oxycodone/ibuprofen) 3rd trimester D.H.E. 45 (dihydroergotamine mesylate) Diflunisal 3rd trimester Etodolac Late pregnancy	Excedrin Migraine (acetaminophen/aspirin/ caffeine) 3rd trimester Fiorinal (butalbital/aspirin/caffeine) 3rd trimester Fiorinal w. Codeine (butalbital/aspirin/ caffeine/codeine phosphate) 3rd trimester Ibudone (hydrocodone bitartrate/ibuprofen) 3rd trimester Ketorolac Late pregnancy Migranal (dihydroergotamine mesylate) Motrin Migraine Pain (ibuprofen) 3rd trimester Nalfon (fenoprofen calcium) 3rd trimester Naprelan (naproxen) 3rd trimester Percodan (oxycodone HCl/aspirin) 3rd trimester Ponstel (mefenamic acid) Late pregnancy Synalgos-DC (dihydrocodeine bitartrate/aspirin/caffeine) 3rd trimester Vicoprofen (hydrocodone bitartrate/ibuprofen) 3rd trimester
RESPIRATORY TRACT
None available
UROGENITAL SYSTEM
Avodart (dutasteride HCl) AVOID HANDLING CAPSULES Caverject (alprostadil) Edex (alprostadil)	Jalyn (dutasteride/tamsulosin HCl) Lithostat (acetohydroxamic acid) Proscar (finasteride) AVOID HANDLING CRUSHED/BROKEN TABLETS
NOTES
*Not an inclusive list. (Rev. 4/2012)
PREGNANCY CATEGORIES
When pregnancy appears as a contraindication or precaution to the use of a drug it is usually qualified by a category.
Cat. A: Adequate studies in pregnant women have failed to show a risk to the fetus in the first trimester and there is no evidence of risk in later trimesters. Cat. B: Animal studies have failed to show a risk to the fetus but there are no adequate studies in pregnant women; or animal studies have shown an adverse effect but human studies have not shown a risk to the fetus in the first trimester and there is no evidence of risk in later trimesters. Cat. C: Animal studies have shown an adverse effect on the fetus but there are no adequate studies in humans, but the benefits may outweigh the risks; or there are no adequate human studies. Cat. D: Positive evidence of human fetal risk but the benefits may outweigh the risks. Cat. X: Animal or human studies have shown fetal abnormalities or toxicity and the risk outweighs the benefits.                                                                                        reference:http://www.empr.com/drugs-contraindicated-in-pregnancy/article/125914/